Interspecies scaling and prediction of human clearance: comparison of small- and macro-molecule drugs

摘要: Human clearance prediction for small- and macro-molecule drugs was evaluated compared using various scaling methods statistical analysis.Human is generally well predicted single or multiple species simple allometry macro- small-molecule excreted renally.The error higher hepatically eliminated small-molecules scaling, it appears that the mainly associated with low hepatic extraction ratio (Eh). The in human reduced a correction of maximum life span (MLP) brain weight (BRW).Human both monkey liver blood flow method. Predictions from other did not work as well, especially drugs.