Dynamic causal modeling of the response to frequency deviants

摘要: This article describes the use of dynamic causal modeling to test hypotheses about genesis evoked responses. Specifically, we consider mismatch negativity (MMN), a well-characterized response deviant sounds and one most widely studied There have been several mechanistic accounts how MMN might arise. It has suggested that results from comparison between sensory input memory trace previous input, although others argued local adaptation, due stimulus repetition, is sufficient explain MMN. Thus precise mechanisms underlying generation remain unclear. study tests some biologically plausible spatiotemporal dipole models rest on changes in extrinsic top-down connections (that enable comparison) intrinsic model adaptation). Dynamic responses deviants are best explained by effective connectivity both within cortical sources hierarchical network distributed sources. Our suggests adaptation operate concert produce early (N1 enhancement) late (MMN) parts frequency deviants. We these light predictive coding inference brain.