Homer1 (VesL-1) in the rat esophagus: focus on myenteric plexus and neuromuscular junction.
作者： J. Zimmermann , W. L. Neuhuber , M. Raab
DOI: 10.1007/S00418-017-1555-7
关键词:
摘要: Homer1, a scaffolding protein of the postsynaptic density (PSD), enriched at excitatory synapses is known to anchor and modulate group I metabotropic glutamate receptors (mGluRs) different channel- receptor-proteins. Homer proteins are expressed in neurons brain regions, but also non-neuronal tissues like skeletal muscle. Occurrence location Homer1 mGluR5 myenteric plexus neuromuscular junctions (NMJ) rat esophagus have yet not been characterized. We located immunoreactivity (-iry) focused on neurons, intraganglionic laminar endings (IGLEs) NMJs, using double- triple-label immunohistochemistry confocal laser scanning microscopy. Homer1-iry was found subpopulation vesicular transporter 2 (VGLUT2) positive IGLEs cholinergic varicosities within ganglia, neither nitrergic nor neuronal cell bodies. detected 63% esophageal and, for comparison, 35% sternomastoid NMJs. Besides PSD, colocalized with markers, indicating presynaptic coarse VAChT/CGRP/NF200- immunoreactive (-ir) terminals nucleus ambiguus supplying striated mGluR5-iry subpopulations bodies, VGLUT2-ir neuropil NMJs muscles. Thus, may sites boutons motor endplates, small ganglia possibly modulating Ca2+-currents neurotransmitter release.
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