Homer protein family regulation in skeletal muscle and neuromuscular adaptation.

摘要: Scaffolding adaptor proteins of the Homer family have recently been implicated in regulation a large number physiological processes owing to their remarkable ability coordinate complex network different molecular players within same signaling pathway. However, because unique properties that also allow functional modulation plethora interacting protein partners, Homers seem play additional and important roles integration several belonging pathways thus allowing crosstalk. The role has previously extensively investigated neuronal tissue where it was first discovered as new being upregulated response brain seizures (Brakeman P.R., et al., Nature 1997, 386, 284–288.). Recently, proposed skeletal muscle physiology. For instance, shown regulate both myogenic differentiation program open probability (Po) ion channels. Furthermore, by knocking out Homer1, one three genes, mice carrying such deletion displayed pronounced myopathy associated with altered transient receptor potential activity calcium homeostasis. expression now further characterized at neuromuscular junction muscle. Apart from known central synapses, are determinants differentiation, development, adaptation system integrating motor neuron control, for example, downstream fibers. © 2013 IUBMB Life, 65(9):769–776,