Computational modeling of flow-induced shear stresses within 3D salt-leached porous scaffolds imaged via micro-CT.

摘要: Abstract Flow-induced shear stresses have been found to be a stimulatory factor in pre-osteoblastic cells seeded 3D porous scaffolds and cultured under continuous flow perfusion. However, due the complex internal structure of scaffolds, analytical estimation local forces is impractical. The primary goal this work investigate stress distributions within Poly( l -lactic acid) via computation. Scaffolds used study are prepared salt leeching with various geometric characteristics (80–95% porosity 215–402.5 μm average pore size). High resolution micro-computed tomography obtain their structure. Flow osteogenic media through modeled lattice Boltzmann method. It that surface characterized by long tails right (a positive skewness). Their shape not strongly dependent on scaffold manufacturing parameters, but magnitudes are. Correlations for experienced probability density function stresses. Though technique does appear affect distributions, presence defects significant: create areas high along periphery. results applicable other polymer systems provided they manufactured similar technique, while imaging/modeling approach all relevant tissue engineering.