Effects of nitric oxide synthase inhibition on regional blood flow in a porcine model of endotoxic shock
作者： Patrick J. Offner , Frank M. Robertson , Basil A. Pruitt
DOI: 10.1097/00005373-199508000-00025
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摘要: The results of early studies suggest that nitric oxide (NO) synthesis inhibition may be therapeutic in sepsis, but recent data indicate NO harmful. This study investigates the effects with N-nitro-L-arginine methyl ester (NAME) on regional blood flow following endotoxemia. Anesthetized, instrumented swine were randomly divided into four groups. Controls received normal saline resuscitation (NSR) at 1 cc/kg/min beginning T 0 . lipopolysaccharide group (LPS) NSR and Escherichia coli LPS, 200 μg/kg LPS + NAME , plus (50 μg/kg/min) starting only NAME. Hemodynamic data, flow, gastric intramucosal pH (pH i ) measured hourly. increased renal carotid consistent a hyperdynamic state. Mesenteric was decreased. Treatment endotoxic animals decreased flow. improved by shock decreasing cardiac output. perfusion ; however, this requires further for validation.
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