Parkinson's disease dementia: a neural networks perspective

摘要: In the long-term, with progression of illness, Parkinson's disease dementia affects up to 90% patients disease. With increasing life expectancy in western countries, is set become even more prevalent future. However, current treatments only give modest symptomatic benefit at best. New are slow development because unlike pathological processes underlying motor deficits disease, neural mechanisms dementing process and its associated cognitive still poorly understood. Recent insights from neuroscience research have begun unravel heterogeneous involvement several distinct networks dementia, their modulation by both dopaminergic non-dopaminergic transmitter systems brain. this review we collate emerging evidence regarding these brain a novel perspective on discuss how may offer new therapeutic opportunities.