Role of histone acetylation in cell physiology and diseases: An update
作者： Shahper N Khan , Asad U Khan , None
DOI: 10.1016/J.CCA.2010.06.020
关键词:
摘要: Although the role of histone acetylation in gene regulation has been subject many reviews, their impact on cell physiology and pathological states proliferation, differentiation genome stability eukaryotic cells remain to be elucidated. Therefore, this review will discuss molecular, physiological biochemical aspects focus interplay acetyltransferases (HATs) deacetylases (HDACs) different disease states. Current treatment strategies are mostly limited enzyme inhibitors, though potential lies targeting other imperative chromatin remodeling factors involved regulation.
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