Hormonal regulation of hepatic amino acid transport.

摘要: The transport of 2-aminoisobutyric acid (AIB) into liver tissue was increased by both insulin and glucagon. We have now shown that these hormones do not stimulate the same system. Glucagon, possibly via cAMP, hepatic uptake AIB a mechanism which resembled system A. This glucagon-sensitive could be monitored use model amino MeAIB. In contrast, insulin-stimulated exhibited little or no affinity for MeAIB will referred to as B. On basis other reports is almost entirely Na+ dependent present finding 2-aminobicyclo [2,2,1] heptane-2-carboxylic (BCH) stimulated either hormone, we conclude B dependent. Furthermore, added perfusate livers from glucagon-pretreated donors suppressed increase in uptake. Depending upon specificities systems A B, are unknown tissue, insulin/glucagon ratio may alter composition intracellular pool acids.