Influenza vaccine effectiveness estimates in Europe in a season with three influenza type/subtypes circulating: the I-MOVE multicentre case-control study, influenza season 2012/13.

摘要: In the fifth season of Influenza Monitoring Vaccine Effectiveness in Europe (I-MOVE), we undertook a multicentre case-control study (MCCS) seven European Union (EU) Member States to measure 2012/13 influenza vaccine effectiveness against medically attended influenza-like illness (ILI) laboratory confirmed as influenza. The was characterised by substantial co-circulation B, A(H1N1)pdm09 and A(H3N2) viruses. Practitioners systematically selected ILI patients swab ≤7 days symptom onset. We compared influenza-positive type/subtype influenza-negative among those who met EU case definition. conducted complete analysis using logistic regression with fixed effect calculated adjusted (AVE), controlling for potential confounders (age, sex, onset week presence chronic conditions). AVE type/subtype. Study sites sent 7,954 ILI/acute respiratory infection records analysis. After applying exclusion criteria, included 4,627 VE B (1,937 cases), 3,516 (1,068 cases) 3,340 (730 cases). 49.3% (95% confidence interval (CI): 32.4 62.0) 50.4% CI: 28.4 65.6) 42.2% 14.9 60.7) A(H3N2). Our results suggest an overall low moderate A(H3N2), between 42 50%. this many co-circulating viruses, high sample size enabled stratified estimates indicate seasonal vaccines should be improved achieve acceptable protection levels. .