Epidemiology of Bordetella pertussis in a children's hospital.

摘要: Introduction. Pertussis or whooping cough continues to be a major cause of morbidity and mortality in infants younger than 1 year old. Objectives. To describe the clinical epidemiological profile Bordetella pertussis analyze factors associated with confirmation by PCR case fatality rate. Material Methods. Prospective, cohort study conducted between December 2003 2011. The included children seen at Hospital de Ninos Ricardo Gutierrez suspected pertussis. rate relative risk (RR) 95% confidence interval were studied. Results. Six hundred twenty patients 38% positive cases (236/620) included, 3 confirmed link. Confirmed (239) showed seasonal pattern from September through February, median age months old, 89% had received less three vaccine doses. Eighty six percent hospitalized: their length stay was 7 days. A total 99% eutrophic, 98% immunocompetent 17.5% required intensive care. presentation analyzed 480 patients. Of them, (184) result symptoms were: 96.2%, cough; 76.5%, paroxysmal 57.9% cyanosis; 55.7%, respiratory distress; 29%, fever; 22.4%, apnea; 21.9%, vomiting after coughing. multivariate analysis identified following as independent predictors PCR: (OR 2.52: 1.50-4.22; p= 0.000) leukocytosis upon admission >20 000 white blood