Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function.

摘要: Glucose homeostasis is finely regulated by a number of hormones and peptides released mainly from the brain, gastrointestinal tract muscle, regulating pancreatic secretion through cellular receptors their signal transduction cascades. The endocrine function pancreas controlled islets within exocrine tissue that release like insulin, glucagon, somatostatin, polypeptide ghrelin. Moreover, both functions are variety hormonal neural mechanisms, such as ghrelin, glucagon-like peptide (GLP-1), glucose-dependent insulinotropic (GIP) or inhibitory somatostatin. In this review, we describe role neurohormones have been less characterized compared to others, on regulation insulin secretion. particular, will focus melatonin, galanin RFamide neuropeptides QRFP26 QRFP43, which display either insulinostatic effects. fact, in addition other hormones, amino acids, cytokines proteins, brain-derived now considered key regulators glucose homeostasis, representing potential therapeutic targets for treatment diabetes obesity.