Tobacco-Smoke-Inducible Human Heme Oxygenase-1 Gene Expression

摘要: Expression of stress-related genes are particularly induced following exposure to thiol-reactive compounds (Heikkila et al., 1982), reactive oxygen intermediates (ROI) (Keyse 1989a, Keyse 1989b, 1990) (Alam 1994), heavy metal cations 1994; Takeda kimberly 1998), UV radiation (Lautier 1992; Vile 1994) and other chemical initiators cellular stress responses such as lipopolysaccharides or hydrogen peroxide (H2O2) (Kurata 1996; Camhi 1995). These stimuli all induce the expression a 32–34kDa protein identified microsomal, inducible, heme oxygenase-1 (HO-1), whose regulation is related heat shock proteins (HSP) in rodents, but not humans (Shibahara 1985; Mitani 1991; Clerget 1990; Pizursky 1990); review showed (Stocker that bile pigments produced by degradation catalyzed HO-1 can function anti-oxidants, while Tyrrell (1989a) demonstrated involved general defence mechanisms against oxidative injury.