Premorbid self-disorders and lifetime diagnosis in the schizophrenia spectrum: a prospective high-risk study.

摘要: Aim The notion of a disordered self as core disturbance schizophrenia was proposed in many foundational texts. Recent studies, spurred by the development Examination Anomalous Self-Experience (EASE), seem to indicate that self-disorders are specific manifestation vulnerability. Follow-up studies help-seeking, prodromal and first-admission patients have demonstrated utility for predicting later schizophrenia-spectrum disturbance. We wished extend these findings gauging predictive value premorbid, non-clinical population at high risk schizophrenia. Methods Children from Copenhagen High-Risk Project with high-genetic (N = 212) were assessed premorbidly (average age = 15), diagnostically re-evaluated after 10 25 years. Since EASE not available time premorbid assessment, we hypothesized proxy scale drawn Minnesota Multiphasic Personality Inventory (MMPI) could distinguish those who developed disorder (N = 68) remained healthy (N = 64). The Self-Disorder Scale comprised 32 items whose content suggested an aspect self-disorder measured EASE. Results Premorbid scores significantly predicted lifetime diagnosis high-risk cohort. Although there considerable item overlap between new existing MMPI (psychoticism), did account Scale's efficacy. Conclusion The results support vulnerability feature schizophrenia, detectable developing disorders.