Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
作者： Di Wang , Mingzhu Zheng , Lei Lei , Jian Ji , Yunliang Yao
DOI: 10.1038/NI.2301
关键词:
摘要: Signaling via the T cell antigen receptor (TCR) during the CD4 + CD8 + double-positive developmental stage determines thymocyte selection and lineage commitment. Here we …
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Josef M. Penninger, Guido Kroemer, Molecular and Cellular Mechanisms of T Lymphocyte Apoptosis Advances in Immunology. ,vol. 68, pp. 51- 144 ,(1998) , 10.1016/S0065-2776(08)60558-1
Ronald N. Germain, T-cell development and the CD4–CD8 lineage decision Nature Reviews Immunology. ,vol. 2, pp. 309- 322 ,(2002) , 10.1038/NRI798
Yonghao Cao, Hai Li, Haifeng Liu, Min Zhang, Zichun Hua, Hongbin Ji, Xiaolong Liu, LKB1 regulates TCR‐mediated PLCγ1 activation and thymocyte positive selection The EMBO Journal. ,vol. 30, pp. 2083- 2093 ,(2011) , 10.1038/EMBOJ.2011.116
S M Hedrick, L P Kane, A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection. Journal of Immunology. ,vol. 156, pp. 4594- 4601 ,(1996)
D. Wang, J. Lou, C. Ouyang, W. Chen, Y. Liu, X. Liu, X. Cao, J. Wang, L. Lu, Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 13806- 13811 ,(2010) , 10.1073/PNAS.1009428107
Ricardo Cibotti, Jennifer A Punt, Krishna S Dash, Susan O Sharrow, Alfred Singer, Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals Immunity. ,vol. 6, pp. 245- 255 ,(1997) , 10.1016/S1074-7613(00)80327-1
Guo Fu, Sébastien Vallée, Vasily Rybakin, Marielena V McGuire, Jeanette Ampudia, Claudia Brockmeyer, Mogjiborahman Salek, Paul R Fallen, John A H Hoerter, Anil Munshi, Yina H Huang, Jianfang Hu, Howard S Fox, Karsten Sauer, Oreste Acuto, Nicholas R J Gascoigne, Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling Nature Immunology. ,vol. 10, pp. 848- 856 ,(2009) , 10.1038/NI.1766
Bruce D. Freedman, Qing-Hua Liu, Selin Somersan, Michael I. Kotlikoff, Jennifer A. Punt, Receptor avidity and costimulation specify the intracellular Ca2+ signaling pattern in CD4(+)CD8(+) thymocytes. Journal of Experimental Medicine. ,vol. 190, pp. 943- 952 ,(1999) , 10.1084/JEM.190.7.943
Claudia Brockmeyer, Wolfgang Paster, David Pepper, Choon P. Tan, David C. Trudgian, Simon McGowan, Guo Fu, Nicholas R. J. Gascoigne, Oreste Acuto, Mogjiborahman Salek, T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. Journal of Biological Chemistry. ,vol. 286, pp. 7535- 7547 ,(2011) , 10.1074/JBC.M110.201236
Rémy Bosselut, CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals Nature Reviews Immunology. ,vol. 4, pp. 529- 540 ,(2004) , 10.1038/NRI1392