Serum stability of peptides.
作者： Håvard Jenssen , Stein Ivar Aspmo
DOI: 10.1007/978-1-59745-419-3_10
关键词:
摘要: … However, issues have been raised regarding the stability of peptide therapeutics for systemic use. The focus of this chapter is assays for measuring peptide stability in the presence of …
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Baptist Gallwitz, New Therapeutic Strategies for the Treatment of Type 2 Diabetes Mellitus Based on Incretins The review of diabetic studies : RDS. ,vol. 2, pp. 61- 69 ,(2005) , 10.1900/RDS.2005.2.61
Michael F. Powell, Tracy Stewart, Laszlo Otvos, Jr, Laszlo Urge, Federico C. A. Gaeta, Alessandro Sette, Thomas Arrhenius, David Thomson, Ken Soda, Sonia M. Colon, Peptide Stability in Drug Development. II. Effect of Single Amino Acid Substitution and Glycosylation on Peptide Reactivity in Human Serum Pharmaceutical Research. ,vol. 10, pp. 1268- 1273 ,(1993) , 10.1023/A:1018953309913
Susan Lorey, Angela Stöckel-Maschek, Jürgen Faust, Wolfgang Brandt, Beate Stiebitz, Mark D. Gorrell, Thilo Kähne, Carmen Mrestani-Klaus, Sabine Wrenger, Dirk Reinhold, Siegfried Ansorge, Klaus Neubert, Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites FEBS Journal. ,vol. 270, pp. 2147- 2156 ,(2003) , 10.1046/J.1432-1033.2003.03568.X
Victor J. Wroblewski, Mechanism of deiodination of 125I-human growth hormone in vivo: Relevance to the study of protein disposition Biochemical Pharmacology. ,vol. 42, pp. 889- 897 ,(1991) , 10.1016/0006-2952(91)90050-F
Karen Bush, Mark Macielag, Michele Weidner-Wells, Taking inventory: antibacterial agents currently at or beyond phase 1. Current Opinion in Microbiology. ,vol. 7, pp. 466- 476 ,(2004) , 10.1016/J.MIB.2004.08.013
Laszlo Otvos, Barbara Cappelletto, Istvan Varga, John D. Wade, Zhi Q. Xiang, Kimberly Kaiser, LaDonna J. Stephens, Hildegund C.J. Ertl, The effects of post-translational side-chain modifications on the stimulatory activity, serum stability and conformation of synthetic peptides carrying T helper cell epitopes Biochimica et Biophysica Acta. ,vol. 1313, pp. 11- 19 ,(1996) , 10.1016/0167-4889(96)00046-8
Ralf Hoffmann, Philippe Bulet, Laszlo Urge, Laszlo Otvös, Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects Biochimica et Biophysica Acta. ,vol. 1426, pp. 459- 467 ,(1999) , 10.1016/S0304-4165(98)00169-X
M. Werle, A. Bernkop-Schnürch, Strategies to improve plasma half life time of peptide and protein drugs Amino Acids. ,vol. 30, pp. 351- 367 ,(2006) , 10.1007/S00726-005-0289-3
Aaron K Sato, Malini Viswanathan, Rachel B Kent, Clive R Wood, Therapeutic peptides: technological advances driving peptides into development Current Opinion in Biotechnology. ,vol. 17, pp. 638- 642 ,(2006) , 10.1016/J.COPBIO.2006.10.002
K OVERBYE, J BARRETT, Antibiotics: where did we go wrong? Drug Discovery Today. ,vol. 10, pp. 45- 52 ,(2005) , 10.1016/S1359-6446(04)03285-4