GLUE that sticks to HIV: a helix-grafted GLUE protein that selectively binds the HIV gp41 N-terminal helical region.
作者： Susanne N. Walker , Rachel L. Tennyson , Alex M. Chapman , Alan J. Kennan , Brian R. McNaughton
关键词:
摘要: Methods for the stabilization of well-defined helical peptide drugs and basic research tools have received considerable attention in last decade. Here, we report stable functional display an HIV gp41 C-peptide helix mimic on a GRAM-Like Ubiquitin-binding EAP45 (GLUE) protein. helix-grafted GLUE selectively binds N-terminal region gp41, well-established drug target, complex cellular environment. Additionally, is folded solution, human serum, soluble aqueous solutions, thus overcomes challenges faced by multitude drugs, including those derived from C-peptide.
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