Inhibition of protein kinase c by long-chain bases
作者： Yusuf Hannun , Robert M. Bell , Carson Loomis
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摘要: Compositions for inhibiting protein kinase C, comprising an inhibitory amount of a compound having formula (I), wherein Q is hydrophobic group; X -CH2-CH2- or -CH=CH-, which may be substituted by one more halogens C1-C3 alkyl groups, Y (II), (III), (IV), (V), (VI), W halogen; R1 and R2 the same different are selected from hydrogen, lower groups 1 to 7 carbon atoms, aralkyl, aryl Z phosphate organic group, pharmaceutically acceptable carrier material; method C using such compositions.
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