Localized delivery of a lipophilic proteasome inhibitor into human skin for treatment of psoriasis.
作者： Meera Gujjar , Jack Arbiser , Rick Coulon , Ajay K. Banga
DOI: 10.3109/1061186X.2015.1087529
关键词:
摘要: AbstractPurpose: Pentaerythritol tetrakis (3,5-di-tert-butyl-4-hydroxyhydrocinnamate) (PTTC) is a cinnamate tetraester with proteasome inhibitor activity, which may be used as topical treatment in psoriasis, but has computed log P of 23. The objective this vitro study was to determine the intradermal delivery, skin irritation and potential efficacy PTTC treating psoriasis.Methods: Solubility studies were performed find suitable vehicle for PTTC. Permeation microneedle-treated skin. A cell culture test dosed positive control, negative control An MTT assay evaluate viability irritancy. Psoriatic also IL-6 levels determined by ELISA.Results: greatest dimethyl sulfoxide ethyl pyruvate, delivering greater amount (2343.41 ± 384.26 µg) into stratum corneum. alone well emulsion formulation f...
sci-hub.se 参考文章(18)
Jack L. Arbiser, Xing-Cong Li, Chowdhury Fiaz Hossain, Dale G. Nagle, David M. Smith, Paul Miller, Baskaran Govindarajan, Josh Di Carlo, Kristin R. Landis-Piwowar, Q. Ping Dou, Naturally Occurring Proteasome Inhibitors from Mate Tea (Ilex paraguayensis) Serve as Models for Topical Proteasome Inhibitors Journal of Investigative Dermatology. ,vol. 125, pp. 207- 212 ,(2005) , 10.1111/J.0022-202X.2005.23809.X
L. Henry, L. Le Gallic, G. Garcin, O. Coux, N. Jumez, P. Roger, T. Lavabre-Bertrand, J. Martinez, L. Meunier, P.E. Stoebner, Proteolytic activity and expression of the 20S proteasome are increased in psoriasis lesional skin. British Journal of Dermatology. ,vol. 165, pp. 311- 320 ,(2011) , 10.1111/J.1365-2133.2011.10447.X
Amitava Mitra, Yunhui Wu, Topical delivery for the treatment of psoriasis Expert Opinion on Drug Delivery. ,vol. 7, pp. 977- 992 ,(2010) , 10.1517/17425247.2010.503953
Alfred Fahr, Peter van Hoogevest, Sylvio May, Nill Bergstrand, Mathew L. S. Leigh, Transfer of lipophilic drugs between liposomal membranes and biological interfaces: consequences for drug delivery. European Journal of Pharmaceutical Sciences. ,vol. 26, pp. 251- 265 ,(2005) , 10.1016/J.EJPS.2005.05.012
R. M. Grossman, J. Krueger, D. Yourish, A. Granelli-Piperno, D. P. Murphy, L. T. May, T. S. Kupper, P. B. Sehgal, A. B. Gottlieb, Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 6367- 6371 ,(1989) , 10.1073/PNAS.86.16.6367
H SCHACKE, Mechanisms involved in the side effects of glucocorticoids Pharmacology & Therapeutics. ,vol. 96, pp. 23- 43 ,(2002) , 10.1016/S0163-7258(02)00297-8
Pallavi V. Pople, Kamalinder K. Singh, Targeting tacrolimus to deeper layers of skin with improved safety for treatment of atopic dermatitis. International Journal of Pharmaceutics. ,vol. 398, pp. 165- 178 ,(2010) , 10.1016/J.IJPHARM.2010.07.008
Cher-Han Tan, Sarah Rasool, Graham A. Johnston, Contact dermatitis: allergic and irritant. Clinics in Dermatology. ,vol. 32, pp. 116- 124 ,(2014) , 10.1016/J.CLINDERMATOL.2013.05.033
Chandra Sekhar Kolli, Ajay K. Banga, Characterization of solid maltose microneedles and their use for transdermal delivery. Pharmaceutical Research. ,vol. 25, pp. 104- 113 ,(2008) , 10.1007/S11095-007-9350-0
Bruce G. Weniger, Gregory M. Glenn, Cutaneous vaccination: antigen delivery into or onto the skin. Vaccine. ,vol. 31, pp. 3389- 3391 ,(2013) , 10.1016/J.VACCINE.2013.05.048