Liver and Fat in Type 2 Diabetes: New Insights and Clinical Relevance

摘要: Among various organs such as the pancreas, kidney, liver, skeletal muscle, and adipose tissue responsible for control of blood glucose levels, liver is emerging one principal involved in insulin resistance associated with type 2 diabetes mellitus. The both short- well long-term maintenance concentrations blood. In diabetes, impaired insulin-mediated suppression production diminished uptake ultimately causes an increase postabsorptive production. Type dysfunction vicious circle between tissue, pancreas leads to other diseases including nonalcoholic fatty disease, cardiovascular complications, cancer. Despite current advances pharmacotherapy attaining optimal glycemic preventing micro- macrovascular diabetic complications has remained intangible daunting. Novel therapeutic targets their modulators, which include protein tyrosine phosphatase 1B inhibitors, glycogen phosphorylase glucokinase activators, diacylglycerol acyltransferase acetyl-CoA carboxylases sirtuin show promising results preclinical clinical studies. Adding new options mechanisms action treatment armamentarium may eventually help improve outcomes reduce burden only possible if we explore understand involvement fats pathogenesis diabetes.