Recent advances in understanding leptin signaling and leptin resistance

Donald J. Marsh, Gunther Hollopeter, Dennis Huszar, Ralph Laufer, Keith A. Yagaloff, Stewart L. Fisher, Paul Burn, Richard D. Palmiter, Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nature Genetics. ,vol. 21, pp. 119- 122 ,(1999) , 10.1038/5070

Airu S. Chen, Donald J. Marsh, Myrna E. Trumbauer, Easter G. Frazier, Xiao-Ming Guan, Hong Yu, Charles I. Rosenblum, Aurawan Vongs, Yue Feng, Linhai Cao, Joseph M. Metzger, Alison M. Strack, Ramon E. Camacho, Theodore N. Mellin, Christian N. Nunes, William Min, Jill Fisher, Shobhna Gopal-Truter, D. Euan MacIntyre, Howard Y. Chen, Lex H.T. Van der Ploeg, Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nature Genetics. ,vol. 26, pp. 97- 102 ,(2000) , 10.1038/79254

Peter Kristensen, Martin E. Judge, Lars Thim, Ulla Ribel, Kennet N. Christjansen, Birgitte S. Wulff, Jes T. Clausen, Per B. Jensen, Ole D. Madsen, Niels Vrang, Philip J. Larsen, Sven Hastrup, Hypothalamic CART is a new anorectic peptide regulated by leptin Nature. ,vol. 393, pp. 72- 76 ,(1998) , 10.1038/29993

Heiko Krude, Heike Biebermann, Werner Luck, Rüdiger Horn, Georg Brabant, Annette Grüters, Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans Nature Genetics. ,vol. 19, pp. 155- 157 ,(1998) , 10.1038/509

Tina M. Hahn, John F. Breininger, Denis G. Baskin, Michael W. Schwartz, Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons Nature Neuroscience. ,vol. 1, pp. 271- 272 ,(1998) , 10.1038/1082

Christian Vaisse, Karine Clement, Bernard Guy-Grand, Philippe Froguel, A frameshift mutation in human MC4R is associated with a dominant form of obesity Nature Genetics. ,vol. 20, pp. 113- 114 ,(1998) , 10.1038/2407

Michael A. Cowley, James L. Smart, Marcelo Rubinstein, Marcelo G. Cerdán, Sabrina Diano, Tamas L. Horvath, Roger D. Cone, Malcolm J. Low, Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus Nature. ,vol. 411, pp. 480- 484 ,(2001) , 10.1038/35078085

Michael P. Myers, Jannik N. Andersen, Alan Cheng, Michel L. Tremblay, Curt M. Horvath, Jean-Patrick Parisien, Annette Salmeen, David Barford, Nicholas K. Tonks, TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B Journal of Biological Chemistry. ,vol. 276, pp. 47771- 47774 ,(2001) , 10.1074/JBC.C100583200

Carl T. Montague, I. Sadaf Farooqi, Jonathan P. Whitehead, Maria A. Soos, Harald Rau, Nicholas J. Wareham, Ciaran P. Sewter, Janet E. Digby, Shehla N. Mohammed, Jane A. Hurst, Christopher H. Cheetham#, Alison R. Earley#, Anthony H. Barnett, Johannes B. Prins, Stephen O'Rahilly, Congenital leptin deficiency is associated with severe early-onset obesity in humans Nature. ,vol. 387, pp. 903- 908 ,(1997) , 10.1038/43185

Deborah J. Burks, Jaime Font de Mora, Markus Schubert, Dominic J. Withers, Martin G. Myers, Heather H. Towery, Shari L. Altamuro, Carrie L. Flint, Morris F. White, IRS-2 pathways integrate female reproduction and energy homeostasis Nature. ,vol. 407, pp. 377- 382 ,(2000) , 10.1038/35030105