Levodopa in Parkinsonism: potentiation of central effects with a peripheral inhibitor.

摘要: Abstract The clinical state achieved with levodopa was compared to that on plus alpha-methyldopa hydrazine, which blocks conversion of dopamine within peripheral tissues only. Five children dystonia remained unimproved by either regimen. In 26 adults Parkinsonism less needed for symptomatic control when given inhibitor than used alone. amount had be added similar doses in patients who received chronically. Rapid induction therapy, better diurnal and a new capability administer pyridoxine receiving constituted advantages adding levodopa. main disadvantage these combinations the rapid involuntary movements.