Blocking the Negative Effects of Pyridoxine on Patients Receiving Levodopa

摘要: To the Editor.— Duvoisin et al 1 reported that administration of pyridoxine may cancel therapeutic and side effects levodopa. This was confirmed in several centers, including our own. 2 Consequently, industry produced marketed a pyridoxine-free preparation (Larobec) which covers needs for vitamins patients receiving While continuing experiments with peripheral metabolic inhibitor D, L-alpha-methyl dopahydrazine or MK 485, 3 we noted diurnal variations performance could be controlled orally administered combinations Such have also diminished striking postprandial reemergence symptoms otherwise experienced by some patients. 2,3 We were thus encouraged to test whether blocked adverse pyridoxine. Pyridoxine (up 100 mg three times each day) given seven at least one week while they ward