Fluid Overload and Mortality in Children Receiving Continuous Renal Replacement Therapy: The Prospective Pediatric Continuous Renal Replacement Therapy Registry

摘要: Background Critically ill children with hemodynamic instability and acute kidney injury often develop fluid overload. Continuous renal replacement therapy (CRRT) has emerged as a favored modality in the management of such children. This study investigated association between overload mortality receiving CRRT. Study Design Prospective observational study. Setting & Participants 297 from 13 centers across United States participating Pediatric CRRT Registry. Predictor Fluid intensive care unit (ICU) admission to initiation, defined percentage equal (fluid [L] − out [L])/(ICU admit weight [kg]) × 100%. Outcome Measurements The primary outcome was survival pediatric ICU discharge. Data were collected regarding demographics, parameters, underlying disease process, severity illness. Results 153 patients (51.5%) developed Limitations an study; interventions not standardized. relationship remains without definitive evidence causality. Conclusions who greater before initiation experience higher than those less Further goal-directed research is required accurately define optimal thresholds for