Somnogenic activity of immune response modifiers
作者： James M. Krueger
DOI: 10.1016/0165-6147(90)90198-H
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摘要: Abstract Sleepiness is a presenting symptom in nearly all infectious diseases . James Krueger describes how microbial products, such as muramyl peptides, lipid A and double-stranded RNA, well endogenous products elicited by tnese substances, interleukin 1, modulate sleep. The altered sleep during infection seems to result from an exaggerated activation of physiological mechanisms, since normal controlled wide range substances including many these immune response modifiers
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