Infarct size as estimated from peak creatine kinase and lactate dehydrogenase is probably reduced in patients using calcium antagonists at the onset of symptoms.

摘要: In animal models, calcium antagonists (Ca-A) administered before ischemia and reperfusion reduced myocardial necrosis, attenuated postischemic contractile dysfunction, tissue calcium. 753 patients with acute infarction (AMI), we examined if use of Ca-A at the onset symptoms (n = 127 patients) infarct size as estimated from peak creatine kinase (CKmax) lactate dehydrogenase (LDmax) activities. The study had an observational exposed/nonexposed design, both crude adjusted effects were investigated. Crude effects: restricted cohort not receiving thrombolytic treatment (thr− pts; n 411 patients), CKmax LDmax lower in Ca-A+ than Ca-A− patients, being 643 versus 887 U/l (2 p 0.004) 708 867 0.005), respectively. When using log (LKmax) outcomes, same results found 0.002). More thr-pts used quartiles (p for linear trend 0.005 0.004 LDmax, respectively). Adjusted Thrombolysis was effect modifier association between enzyme levels. thr-pts, coefficients negative borderline significant (CKmax; 2 0.088) highly (LDmax; 0.010) when adjusting confounders. present indicates that a AMI reduces size,