Patterns of Creatine Kinase Release During Acute Myocardial Infarction After Nonsurgical Reperfusion: Comparison With Conventional Treatment and Correlation With Infarct Size

摘要: Coronary arteriography and biplane ventriculography were performed in 51 patients during the acute (mean of 6.6 hours after onset symptoms) chronic (1 to 3 months admission) phase myocardial infarction. Twenty-four treated a conventional manner. In 27 patients, reperfusion was achieved with intracoronary streptokinase 24 ± 20 minutes infusion. Peak creatine kinase cumulative release derived from serial measurements. Ejection fraction length akinetic or dyskinetic segments calculated phase. The time interval between symptoms peak significantly shorter for streptokinase-treated as compared conventionally (13.5 5.3 versus 22.9 7.4 hours, p = 0.0001). Significant linear correlations obtained both control relating: 1) value noncontracting segment ejection phase, 2) Patients experienced relatively greater enzyme given infarct size those difference two groups increased increased. These observations may be explained by enhanced washout zone, secondary therapy. variability observed small infarcts suggests that prediction an individual patient time-activity curves should made caution.