Serum CK-MB in Diagnosis and Assessment of Acute Myocardial Infarction

摘要: When coronary care units were first developed in the early 1960s, it became important to make a prompt diagnosis regarding presence or absence of an acute myocardial infarct (AMI) optimize use these specialized facilities. This was extremely difficult when no new Q waves appeared on electrocardiogram (ECG) during 24–48 h following CCU admission. Total “cardiac” enzyme determinations alternative, and glutamic oxaloacetic transaminase (SGOT), lactic dehydrogenase (LDH), creatine kinase (CK) all remained within normal limits, excluded. However, variety other body tissues could be source transient elevations each enzymes. The attempt specifically identify tissue origin electrophoretic method for separating isoenzymes LDH [1]. improvement over total still suboptimal, because (a) elevation LDH1 result from hemolysis as well necrosis, (b) results expressed ratios one isoenzyme (LDH1) another (LDH2) rather than absolute level particular isoenzyme.