Lipid hydrolysis therapy for atherosclerosis and related diseases
作者： Hong Du , Gregory A. Grabowski
DOI:
关键词:
摘要: The present invention comprises a method to diminish and/or eliminate atherosclerotic plaques, in mammals, through direct and indirect treatment of these situ, using suitable substances which are capable lipid removal, primarily hydrolysis, either by catalytic or stoichiometric process, wherein the substance targets receptors on cell lead uptake into lysosome. Such used plaques generally comprised hydrolyzing proteins polypeptides.
lens.org 参考文章(293)
E. Mayatepek, U. Seedorf, H. Wiebusch, H. Lenhartz, G. Assmann, Fatal genetic defect causing Wolman disease Journal of Inherited Metabolic Disease. ,vol. 22, pp. 93- 94 ,(1999) , 10.1023/A:1005428122457
Mary Teresa Moran, J. Paul Schofield, Alison R. Hayman, Guo-Ping Shi, Elisabeth Young, Timothy M. Cox, Pathologic gene expression in Gaucher disease: up-regulation of cysteine proteinases including osteoclastic cathepsin K. Blood. ,vol. 96, pp. 1969- 1978 ,(2000) , 10.1182/BLOOD.V96.5.1969
A. R. Carter, N. E. France, B. W. Lewis, D. G. Shaw, Cholesterol Ester Storage Disease Pediatric Radiology. ,vol. 2, pp. 135- 136 ,(1974) , 10.1007/BF01314945
E R Maher, F M Richards, A R Webster, N A Affara, A H Prowse, F Resche, S Richard, S Olschwang, Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors. American Journal of Human Genetics. ,vol. 60, pp. 765- 771 ,(1997)
Donald S. Karanewsky, Phosphorus-containing HMG-CoA reductase inhibitor compounds ,(1990)
W. Krivit, D. Freese, Roshni Kulkarni, Ka Wa Chan, Wolman's disease: a review of treatment with bone marrow transplantation and considerations for the future. Bone Marrow Transplantation. ,vol. 10, pp. 97- 101 ,(1992)
Robert J. Desnick, Gregory A. Grabowski, Advances in the Treatment of Inherited Metabolic Diseases Advances in human genetics. ,vol. 11, pp. 281- 369 ,(1981) , 10.1007/978-1-4615-8303-5_5
T.G. Warner, L.M. Dambach, J.H. Shin, J.S. O'Brien, Purification of the lysosomal acid lipase from human liver and its role in lysosomal lipid hydrolysis. Journal of Biological Chemistry. ,vol. 256, pp. 2952- 2957 ,(1981) , 10.1016/S0021-9258(19)69707-3
Kenneth B. Pomerantz, Andrew C. Nicholson, Orli Etingin, Barbara Summers, David P. Hajjar, Biochemical Mechanisms Associated with the Lipolytic Effects of Calcium Channel Blockers Springer, Dordrecht. pp. 251- 260 ,(1993) , 10.1007/978-94-011-1703-6_31
Sari Lusa, Pentti Somerharju, Degradation of low density lipoprotein cholesterol esters by lysosomal lipase in vitro. Effect of core physical state and basis of species selectivity. Biochimica et Biophysica Acta. ,vol. 1389, pp. 112- 122 ,(1998) , 10.1016/S0005-2760(97)00164-1