Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models
作者： Isabel Yasmin Buchsbaum , Silvia Cappello
DOI: 10.1242/DEV.163766
关键词:
摘要: Neuronal migration is a fundamental process that governs embryonic brain development. As such, mutations affect essential neuronal processes lead to severe malformations, which can cause complex and heterogeneous developmental disorders. Our fragmented knowledge about the aetiology of these disorders raises numerous issues. However, many now be addressed through studies in vivo vitro models attempt recapitulate human-specific mechanisms cortical In this Review, we discuss advantages limitations model systems suggest complementary approach, using combinations models, will broaden our molecular cellular underlie defective positioning human cerebral cortex.
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