Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD).

摘要: ABSTRACTIntroduction: Club cell protein 16 (CC16) is the most abundant in bronchoalveolar lavage fluid. CC16 has anti-inflammatory properties smoke-exposed lungs, and chronic obstructive pulmonary disease (COPD) associated with deficiency. Herein, we explored whether a therapeutic target for COPD.Areas Covered: We reviewed literature on factors that regulate airway expression, its biologic functions protective activities lungs using PUBMED searches. generated hypotheses mechanisms by which limits COPD development, discuss potential as new approach COPD.Expert Opinion: plasma lung levels are reduced smokers without airflow obstruction patients. In patients, expression inversely correlated severity of obstruction. deficiency increases smoke-induced pathologies mice effects epithelial cells, leukocytes, fibroblasts. Experime...