Uteroglobin promoter-targeted c-MYC expression in transgenic mice cause hyperplasia of Clara cells and malignant transformation of T-lymphoblasts and tubular epithelial cells.
作者： Anke Geick , Peter Redecker , Anja Ehrhardt , Rainer Klocke , Dieter Paul
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摘要: To investigate the influence of proto-oncogene c-MYC on tumor development in different epithelial tissues which secrete Clara Cell Secretory Protein (uteroglobin, UG), transgenic mouse lines were established expressing human under control rabbit UG-promoter. These mice expressed transgene cells and other UG like uterus prostate. In bronchioalveolar epithelium lung hyperplasias developed originating from cells. Surprisingly, transgenics most frequently T-lymphoblastic lymphomas, a polycystic kidney phenotype renal cell carcinoma derived tubular cells, are both that had so far not been known to express UG. Immunohistological studies UG/MYC line (UG/eGFP) Green Fluorescent confirmed uteroglobin promoter is only active but also lymphatic tissue. The will be useful biochemical mechanisms underlying carcinomas oncogenic properties various tissues.
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