HepaCAM induces G1 phase arrest and promotes c‐Myc degradation in human renal cell carcinoma

作者: Qiao-Lin Zhang , Chun-Li Luo , Xiao-Hou Wu , Chun-Yuan Wang , Xin Xu

DOI: 10.1002/JCB.23207

关键词: HEPACAMCell biologyEctopic expressionCell growthCellDownregulation and upregulationMG132BiologyCell cyclePhosphorylation

摘要: … be responsible for the relatively short life of the c-Myc protein [Salghetti et al., 1999]. To determine whether the degradation process was associated with loss of c-Myc, cells were treated …

参考文章(35)
Anke Geick, Peter Redecker, Anja Ehrhardt, Rainer Klocke, Dieter Paul, Roman Halter, Uteroglobin promoter-targeted c-MYC expression in transgenic mice cause hyperplasia of Clara cells and malignant transformation of T-lymphoblasts and tubular epithelial cells. Transgenic Research. ,vol. 10, pp. 501- 511 ,(2001) , 10.1023/A:1013085228119
Markus Welcker, Amir Orian, Jianping Jin, Jonathan A. Grim, J. Wade Harper, Robert N. Eisenman, Bruce E. Clurman, The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 9085- 9090 ,(2004) , 10.1073/PNAS.0402770101
Simone E Salghetti, So Young Kim, William P Tansey, Destruction of Myc by ubiquitin‐mediated proteolysis: cancer‐associated and transforming mutations stabilize Myc The EMBO Journal. ,vol. 18, pp. 717- 726 ,(1999) , 10.1093/EMBOJ/18.3.717
Mei Chung Moh, Chunli Zhang, Chunli Luo, Lay Hoon Lee, Shali Shen, Structural and Functional Analyses of a Novel Ig-like Cell Adhesion Molecule, hepaCAM, in the Human Breast Carcinoma MCF7 Cells Journal of Biological Chemistry. ,vol. 280, pp. 27366- 27374 ,(2005) , 10.1074/JBC.M500852200
C. Elizabeth Caldon, Roger J. Daly, Robert L. Sutherland, Elizabeth A. Musgrove, Cell cycle control in breast cancer cells Journal of Cellular Biochemistry. ,vol. 97, pp. 261- 274 ,(2006) , 10.1002/JCB.20690
Diego F Calvisi, Sara Ladu, Elizabeth A Conner, Valentina M Factor, Snorri S Thorgeirsson, Disregulation of E-cadherin in transgenic mouse models of liver cancer Laboratory Investigation. ,vol. 84, pp. 1137- 1147 ,(2004) , 10.1038/LABINVEST.3700147
Tong-Chuan He, Andrew B Sparks, Carlo Rago, Heiko Hermeking, Leigh Zawel, Luis T Da Costa, Patrice J Morin, Bert Vogelstein, Kenneth W Kinzler, None, Identification of c-MYC as a Target of the APC Pathway Science. ,vol. 281, pp. 1509- 1512 ,(1998) , 10.1126/SCIENCE.281.5382.1509
Mei Chung Moh, Qifeng Tian, Ting Zhang, Lay Hoon Lee, Shali Shen, The immunoglobulin‐like cell adhesion molecule hepaCAM modulates cell adhesion and motility through direct interaction with the actin cytoskeleton Journal of Cellular Physiology. ,vol. 219, pp. 382- 391 ,(2009) , 10.1002/JCP.21685