Novel peptides targeting the hepatocyte growth factor receptor c-Met for the treatment of cancer
作者： Neil R Michaud
DOI: 10.1517/13543776.15.5.621
关键词:
摘要: Dysregulated growth factor signalling is an important hallmark of cancer. The receptor tyrosine kinase c-Met has been implicated in the development many carcinomas and sarcomas, multiple therapeutic approaches to target hepatocyte (HGF)/c-Met axis are being pursued by several companies. Here, monomeric peptides or chemically-conjugated multimeric polypeptides that antagonise binding HGF abrogate function claimed as a treatment for
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