Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
作者： Pankaj Kapahi , Brian M Zid , Tony Harper , Daniel Koslover , Viveca Sapin
DOI: 10.1016/J.CUB.2004.03.059
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摘要: In many species, reducing nutrient intake without causing malnutrition extends lifespan [1–3]. Like DR (dietary restriction), modulation of genes in the insulin-signaling pathway, known to alter nutrient sensing, has been shown to extend lifespan in various species [1–4]. In Drosophila, the target of rapamycin (TOR) and the insulin pathways have emerged as major regulators of growth and size. Hence we examined the role of TOR pathway genes in regulating lifespan by using Drosophila. We show that inhibition of TOR signaling pathway …
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