Behavioral impairments in acute and chronic manganese poisoning in white rats.
作者： A. Shukakidze , I. Lazriev , N. Mitagvariya
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摘要: Single p.o. doses of manganese chloride (MnCl2·4H2O; 50 mg/kg) induced significant and reversible decreases in total activity white rats, along with worsening the acquisition an avoidance reaction response to unconditioned conditioned stimuli, increases latent period reflex activity, a temporary learning process. Chronic poisoning (daily at 20 or mg/kg for one month) led impairment processes multipath maze but had no effect on reproduction previously acquired stereotypical behavior.
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sci-hub.se 参考文章(12)
Donna B. McKean, Jack Pearl, Avoidance box for mice Physiology & Behavior. ,vol. 3, pp. 795- IN22 ,(1968) , 10.1016/0031-9384(68)90154-6
Mau-Sun Hua, Chi-Chang Huang, Chronic occupational exposure to manganese and neurobehavioral function Journal of Clinical and Experimental Neuropsychology. ,vol. 13, pp. 495- 507 ,(1991) , 10.1080/01688639108401066
Ümit Kemal Şentürk, Gülsen Öneŕ, The effect of manganese-induced hypercholesterolemia on learning in rats Biological Trace Element Research. ,vol. 51, pp. 249- 257 ,(1996) , 10.1007/BF02784079
M. Christopher Newland, Bernard Weiss, Persistent effects of manganese on effortful responding and their relationship to manganese accumulation in the primate globus pallidus Toxicology and Applied Pharmacology. ,vol. 113, pp. 87- 97 ,(1992) , 10.1016/0041-008X(92)90012-H
Satya V. Chandra, M. Mohd. Ali, D. K. Saxena, R. C. Murthy, Behavioral and neurochemical changes in rats simultaneously exposed to manganese and lead. Archives of Toxicology. ,vol. 49, pp. 49- 56 ,(1981) , 10.1007/BF00352071
C.-C. Huang, N.-S. Chu, C.-S. Lu, J.-D. Wang, J.-L. Tsai, J.-L. Tzeng, E. C. Wolters, D. B. Calne, Chronic manganese intoxication JAMA Neurology. ,vol. 46, pp. 1104- 1106 ,(1989) , 10.1001/ARCHNEUR.1989.00520460090018
G. Öner, Ü.K. ŞentÜrk, Reversibility of manganese-induced learning defect in rats. Food and Chemical Toxicology. ,vol. 33, pp. 559- 563 ,(1995) , 10.1016/0278-6915(95)00020-3
Girja S. Shukla, Radhey L. Singhal, The present status of biological effects of toxic metals in the environment: lead, cadmium, and manganese. Canadian Journal of Physiology and Pharmacology. ,vol. 62, pp. 1015- 1031 ,(1984) , 10.1139/Y84-171
I. Sziráki, K.P. Mohanakumar, P. Rauhala, H.G. Kim, K.J. Yeh, C.C. Chiueh, Manganese: a transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of parkinsonism. Neuroscience. ,vol. 85, pp. 1101- 1111 ,(1998) , 10.1016/S0306-4522(97)00660-X
M. Yamada, S. Ohno, I. Okayasu, R. Okeda, S. Hatakeyama, H. Watanabe, K. Ushio, H. Tsukagoshi, Chronic manganese poisoning: A neuropathological study with determination of manganese distribution in the brain Acta Neuropathologica. ,vol. 70, pp. 273- 278 ,(1986) , 10.1007/BF00686083