Behavioral and neurochemical changes in rats simultaneously exposed to manganese and lead.
作者： Satya V. Chandra , M. Mohd. Ali , D. K. Saxena , R. C. Murthy
DOI: 10.1007/BF00352071
关键词: Internal medicine 、 Lead (electronics) 、 Endocrinology 、 Manganese 、 Combined treatment 、 Neurochemical 、 Biochemistry 、 Norepinephrine (medication) 、 Dose 、 Lead acetate 、 Dopamine 、 Chemistry
摘要: Groups of rats were exposed simultaneously to manganese chloride (3 mg Mn2+/ml water) through drinking water and lead acetate intraperitoneally at dosages 5.0, 8.0 12.0 Pb2+/kg daily for a period 14 days. The magnitude changes in the behavioral pattern, contents biogenic amines accumulation brain two metals was significantly greater than observed after exposure either alone. A definite dose-response relationship was, however, noticed only with motoractivity, norepinephrine, 5-hydroxytryptamine levels lead. lowering norepinephrine combined treatment found be related decrease motoractivity rats. exact role depression dopamine inducing marked impairment learning ability increased aggressive behavior could not ascertained. overall analysis data indicated that simultaneous lead, particularly highest dose latter, may produce serious derangements pattern
springer.com
sci-hub.se 参考文章(10)
G.F. Nordberg, H.H. Sandstead, B.A. Fowler, M. Piscator, A. Jernelov, L. Friberg, N. Nelson, Factors influencing metabolism and toxicity of metals: a consensus report Environ. Health Perspect.; (United States). ,vol. 25, ,(1978)
N P Singh, I S Thind, L F Vitale, M Pawlow, Lead content of tissues of baby rats born of, and nourished by lead-poisoned mothers. Journal of Laboratory and Clinical Medicine. ,vol. 87, pp. 273- 280 ,(1976)
H T Delves, B E Clayton, J Bicknell, Concentration of trace metals in the blood of children. Journal of Epidemiology & Community Health. ,vol. 27, pp. 100- 107 ,(1973) , 10.1136/JECH.27.2.100
M M Joselow, E Tobias, R Koehler, S Coleman, J Bogden, D Gause, Manganese pollution in the city environment and its relationship to traffic density. American Journal of Public Health. ,vol. 68, pp. 557- 560 ,(1978) , 10.2105/AJPH.68.6.557
Leonard Cook, Edwin Weidley, BEHAVIORAL EFFECTS OF SOME PSYCHOPHARMACOLOGICAL AGENTS Annals of the New York Academy of Sciences. ,vol. 66, pp. 740- 752 ,(1957) , 10.1111/J.1749-6632.1957.TB40763.X
M Golter, I. Michaelson, Growth, behavior, and brain catecholamines in lead-exposed neonatal rats: a reappraisal Science. ,vol. 187, pp. 359- 361 ,(1975) , 10.1126/SCIENCE.1167426
J. Donaldson, T. St. Pierre, J. L. Minnich, A. Barbeau, Determination of Na+, K+, Mg2+, Cu2+, Zn2+, and Mn2+ in Rat Brain Regions Canadian Journal of Biochemistry. ,vol. 51, pp. 87- 92 ,(1973) , 10.1139/O73-010
CHIRAVAT SADAVONGVIVAD, Pharmacological significance of biogenic amines in the lungs: 5-hydroxytryptamine. British Journal of Pharmacology. ,vol. 38, pp. 353- 365 ,(1970) , 10.1111/J.1476-5381.1970.TB08523.X
E. F. Van Maanen, W. L. Kuhn, Central nervous system effects of thalidomide. Journal of Pharmacology and Experimental Therapeutics. ,vol. 134, pp. 60- 68 ,(1961)
Edwin J. Fellows, Ralph E. Tedeschi, David H. Tedeschi, Leonard Cook, Paul A. Mattis, Anna Mucha, Effects of various centrally acting drugs on fighting behavior of mice. Journal of Pharmacology and Experimental Therapeutics. ,vol. 125, pp. 28- 34 ,(1959)