Chromosome I Controls Chromosome II Replication in Vibrio cholerae

摘要: Control of chromosome replication involves a common set regulators in eukaryotes, whereas bacteria with divided genomes use chromosome-specific regulators. How bacterial chromosomes might communicate for is not known. In Vibrio cholerae, which has two (chrI and chrII), initiation controlled by DnaA chrI RctB chrII. binding sites at the origin as well outside origin. likewise binds chrII and, shown here, to external sites. The inhibits replication. A new kind site was found that enhances Consistent its enhancing activity, increased those stimulate decreased other inhibit differential effect on suggests remodels RctB. chaperone-like activity supported finding it could relieve dependence chaperone proteins DnaJ DnaK. presence specifically controls mechanism communication between