Bone marrow stromal cells are load responsive in vitro

摘要: Mechanical load-related effects on bone marrow stromal cellsin vitro have been investigated. A dose response of a cyclical load 1 Hz between 350 ustrain and 2500 applied to 10-day-old cultures resulted in elevated alkaline phosphatase levels the number cells expressing this protein after 2 days. No significant changes or production collagen type I was observed. critical stage development must be reached before elevation expression could measured independent at which loading applied. Using prostaglandin inhibitor concentrations previously usedin vivo, abolished. We demonstrated that are responsive culture made preliminary studies into determining involvement prostaglandins process.