The Design of Analgesic Clinical Trials

摘要: In this text specialists in the area of analgesic trial design present a guide to clinical evaluation agents and methods for acute chronic pain control. The material book deals with topics such as drug studies, tailoring designs patients specific diseases, probing neural mechanisms pain, integrating recent advances pharmacokinetics statistics, studying effectiveness efforts improve clinicians' practice. For investigators properties potential compounds, reviews regulatory requirements, describes most efficient ways screen efficacy toxicity, explains how plan series controlled trials, choosing from many standard "pain models". clinicians seeking improved strategies relief, presents trials types postoperative neuropathic syndromes, cancer low back osteoarthritis, sickle cell disease, sports injuries, orofacial headache dysmenorrhea. Also included are discussions new methodologies studies - multiple dose studies; comparing spinal, transdermal, other novel routes oral or systemic administration; patient-controlled analgesia paradigms; prescribing practices; biostatistics. Following chapters commentaries by experts research that highlight unresolved issues ongoing controversies.