Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies.

Yi Zhu, Tamara Tchkonia, Tamar Pirtskhalava, Adam C. Gower, Husheng Ding, Nino Giorgadze, Allyson K. Palmer, Yuji Ikeno, Gene B. Hubbard, Marc Lenburg, Steven P. O'Hara, Nicholas F. LaRusso, Jordan D. Miller, Carolyn M. Roos, Grace C. Verzosa, Nathan K. LeBrasseur, Jonathan D. Wren, Joshua N. Farr, Sundeep Khosla, Michael B. Stout, Sara J. McGowan, Heike Fuhrmann‐Stroissnigg, Aditi U. Gurkar, Jing Zhao, Debora Colangelo, Akaitz Dorronsoro, Yuan Yuan Ling, Amira S. Barghouthy, Diana C. Navarro, Tokio Sano, Paul D. Robbins, Laura J. Niedernhofer, James L. Kirkland, The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs Aging Cell. ,vol. 14, pp. 644- 658 ,(2015) , 10.1111/ACEL.12344

Carolyn M. Roos, Bin Zhang, Allyson K. Palmer, Mikolaj B. Ogrodnik, Tamar Pirtskhalava, Nassir M. Thalji, Michael Hagler, Diana Jurk, Leslie A. Smith, Grace Casaclang‐Verzosa, Yi Zhu, Marissa J. Schafer, Tamara Tchkonia, James L. Kirkland, Jordan D. Miller, Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice Aging Cell. ,vol. 15, pp. 973- 977 ,(2016) , 10.1111/ACEL.12458

Ming Xu, Elizabeth W. Bradley, Megan M. Weivoda, Soyun M. Hwang, Tamar Pirtskhalava, Teresa Decklever, Geoffry L. Curran, Mikolaj Ogrodnik, Diana Jurk, Kurt O. Johnson, Val Lowe, Tamar Tchkonia, Jennifer J. Westendorf, James L. Kirkland, Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice Journals of Gerontology Series A-biological Sciences and Medical Sciences. ,vol. 72, pp. 780- 785 ,(2016) , 10.1093/GERONA/GLW154

James L. Kirkland, Tamara Tchkonia, Cellular Senescence: A Translational Perspective. EBioMedicine. ,vol. 21, pp. 21- 28 ,(2017) , 10.1016/J.EBIOM.2017.04.013

Jamie N Justice, Heather Gregory, Tamar Tchkonia, Nathan K LeBrasseur, James L Kirkland, Stephen B Kritchevsky, Barbara J Nicklas, Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women. Journals of Gerontology Series A-biological Sciences and Medical Sciences. ,vol. 73, pp. 939- 945 ,(2018) , 10.1093/GERONA/GLX134

Joshua N Farr, Ming Xu, Megan M Weivoda, David G Monroe, Daniel G Fraser, Jennifer L Onken, Brittany A Negley, Jad G Sfeir, Mikolaj B Ogrodnik, Christine M Hachfeld, Nathan K LeBrasseur, Matthew T Drake, Robert J Pignolo, Tamar Pirtskhalava, Tamara Tchkonia, Merry Jo Oursler, James L Kirkland, Sundeep Khosla, Targeting cellular senescence prevents age-related bone loss in mice Nature Medicine. ,vol. 23, pp. 1072- 1079 ,(2017) , 10.1038/NM.4385

Ming Xu, Tamar Pirtskhalava, Joshua N. Farr, Bettina M. Weigand, Allyson K. Palmer, Megan M. Weivoda, Christina L. Inman, Mikolaj B. Ogrodnik, Christine M. Hachfeld, Daniel G. Fraser, Jennifer L. Onken, Kurt O. Johnson, Grace C. Verzosa, Larissa G. P. Langhi, Moritz Weigl, Nino Giorgadze, Nathan K. LeBrasseur, Jordan D. Miller, Diana Jurk, Ravinder J. Singh, David B. Allison, Keisuke Ejima, Gene B. Hubbard, Yuji Ikeno, Hajrunisa Cubro, Vesna D. Garovic, Xiaonan Hou, S. John Weroha, Paul D. Robbins, Laura J. Niedernhofer, Sundeep Khosla, Tamara Tchkonia, James L. Kirkland, Senolytics improve physical function and increase lifespan in old age Nature Medicine. ,vol. 24, pp. 1246- 1256 ,(2018) , 10.1038/S41591-018-0092-9

Nicolas Musi, Joseph M. Valentine, Kathryn R. Sickora, Eric Baeuerle, Cody S. Thompson, Qiang Shen, Miranda E. Orr, Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell. ,vol. 17, ,(2018) , 10.1111/ACEL.12840