MAP Kinase Pathway

摘要: The MAP kinase pathway (or, better, the pathways) is certainly one of main proliferation pathways, best known and whose oncogenic alterations have elicited highest number studies devoted to these alterations. This activated downstream numerous membrane receptors, especially those EGF receptor family, leads ultimately activation transcription factors called MAPs (mitogen-activated proteins), which govern genes required for DNA replication cell division. Besides classical pathway, known, will be presented in detail, several parallel pathways been identified. They are by other stimuli lead involved stress response, inflammation development, rather than proliferation.