Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children.

摘要: In this study, we compare the morphological and genetic characteristics of 38 post-Chernobyl thyroid papillary carcinomas from Belarussian children 5-18 years old with those 23 sporadic same age without history radiation exposure Los Angeles Cincinnati. Among radiation-induced tumors, solid variant carcinoma was found in 37%, follicular 29%, typical 18%, mixed diffuse sclerosing variants 8% each. group, a pattern prevalent 70%, 17%, 9%, 4%. both groups, prevalence ret rearrangements high, but frequency specific types rearrangement significantly different. ret/PTC3 58%, ret/PTC1 16%, ret/PTC2 3%, whereas among 47% (P < 0.05), 18% = 0.01). The showed different rearrangement. Seventy-nine % tumors had ret/PTC3, only 7% 0.0007). 38%, 19%, 5%. Thus, are highly pediatric exposed to occurring sporadically. However, ret/PTC vary between these two populations, present more commonly tumors. Furthermore, have high do not, suggesting that confer neoplastic cells distinct phenotypic properties.