Measurement of Conductive Hearing Loss in Mice

摘要: Abstract In order to discriminate conductive hearing loss from sensorineural impairment, quantitative measurements were used evaluate the effect of artificial pathology on distortion-product otoacoustic emissions (DPOAEs), auditory brainstem responses (ABRs) and laser-Doppler vibrometry (LDV) in mice. The manipulations created by perforating pars flaccida tympanic membrane, filling or partially middle-ear cavity with saline, fixing ossicular chain, interrupting incudo-stapedial joint. saline-filled ossicular-fixation groups, averaged DPOAE thresholds increased relative control state 20–36 25–39 dB, respectively largest threshold shifts occurring at frequencies less than 20 kHz, while ABR 12–19 12–25 dB, without predominant low-frequency effect. Both elevated 10 dB half-filled saline condition; no significant change was observed after perforation. Conductive generally produced a dB that 1.5–2.5 times larger 30 kHz; changes two nearly equal highest frequencies. While mild (ABR 10 dB) associated deceases growth rate. Our LDV are consistent others suggest umbo velocity not an accurate indicator lesions