Clinical Significance of Immunohistochemical Expression of Hypoxia-Inducible Factor–1α as a Prognostic Marker in Rectal Adenocarcinoma
作者： Xue-guan Lu , Chun-gen Xing , Yi-zhong Feng , Jie Chen , Chong Deng
关键词:
摘要: Background Hypoxia-inducible factor–1α (HIF-1α), a subunit of hypoxia-inducible factor–1 (HIF-1), furnishes tumor cells with the means adapting to stress parameters, such as hypoxia, and promotes critical steps in progression aggressiveness by inducing angiogenesis regulating energy metabolism. In this study, we investigated relationship between HIF-1α vascular endothelial growth factor (VEGF) clinicopathologic characteristics, evaluated role expression patients rectal adenocarcinoma.
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