Characterization of antioxidants present in hawthorn fruits
作者： Zesheng Zhang , Qi Chang , Min Zhu , Yu Huang , Walter K.K. Ho
DOI: 10.1016/S0955-2863(00)00137-6
关键词:
摘要: Hawthorn fruit extract has been shown to have many health benefits including being cardiovascular protective, hypotensive and hypocholesterolemic. The present study was carried out characterize further the antioxidants of hawthorn their effect on oxidation human low density lipoprotein (LDL) alpha-tocopherol. dry extracted successively with ether, ethyl acetate, butanol water. acetate fraction only effective in inhibition Cu(+2)-mediated LDL oxidation. column chromatographic separation led isolation eight pure compounds; namely, ursolic acid, hyperoside, isoquercitrin, epicatechin, chlorogenic quercetin, rutin protocatechuic acid. All these phenolic compounds, except were protective from They also preventing peroxy free radical-induced alpha-tocopherol LDL. inhibitory compounds dose-dependent at concentrations ranging 5 40 µM. In addition, supplementation 2% powder significantly elevated serum by 18-20% rats fed a 30% polyunsaturated canola oil diet, as compared control. results suggest that part mechanism for effects might involve direct protection or indirect via maintaining concentration
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