The clinical significance of p53 accumulation in gastric carcinoma

摘要: BACKGROUND. Alterations in the expression of p53 tumor suppressor protein is a frequent event human cancer but practical implications this phenomenon are yet to be fully exploited. The objective study was determine value accumulation as marker progression and prognosis gastric carcinoma patients evaluate whether parameter can properly assessed prior surgery. METHODS. studied immunohistochemically 200 carcinomas using paraffin embedded surgical specimens endoscopic biopsies. correlation between tissue, selected clinicopathologic variables, course patients' disease were analyzed. RESULTS. Results showed that 42.5% expressed elevated levels protein. P53 positivity correlated with increasing stage size (P < 0.001 P = 0.025, respectively). positive tumors had higher propensity for lymph node distant metastases 0.001). also more frequently detected from proximal rather than distal stomach 0.027). In receiving potentially curative resection advanced cancer, an independent strongest poor (RR 3.7, There complete concordance immunohistochemical detection material. CONCLUSIONS. A preoperative assessment helpful identify at high risk metastatic spread regional nodes independently those especially prognosis. When combined routine procedures, simple inexpensive test might allow appropriate planning better treatment strategies.