Prognostic significance of biological apoptosis factors in gastric cancer.

摘要: Summary Purpose: Gastric cancer is a biologically heterogeneous disease containing many genetic and epigenetic alterations. In our study, the expression status of apoptosis-inducing p53 apoptosis-inhibiting Bcl-2 in gastric their relation with prognosis, if any, was investigated. Methods: Patients that were being followed clinic had histopathologically diagnosed adenocarcinoma included this study. The bcl-2 expressions investigated immunohistochemi cally patients grouped according to as follows: group A: both negative; B: positive C: negative positive; D: positive. Results: 19 (51.4%) immunostaining observed, while 18 (48.6%). A significant relationship between metastatic ability tumor determined (p=0.004). 78.6% tumors no 69.6% non-metastatic No detected survival. Positive observed 9 (16.7%) patients, 45 (83.3%). depth invasion, dissemination lymph nodes tumor. borderline statistically deter mined survival (p=0.051). Group B showed difference compared other groups (p=0.022). Conclusion: results study suggest concurrent evaluation gas tric may have prognostic importance.