Influence of central nervous system-acting drugs on results of cognitive testing in geriatric inpatients

摘要: Growing evidence shows a high correlation between extensive use of central nervous system-acting drugs (CNSADs) in elderly patients and adverse drug reactions (ADRs) such as falls, fractures, mortality. Are results cognitive testing with the Mini Mental Status Examination (MMSE) influenced by CNSADs? Geriatric inpatient service for acute, subacute, rehabilitation care. Secondary combined analysis two prospective, single-center study cohorts (PROPSYC, 2011 AGE OUT, 2012) identical procedure MMSE at tertiary hospital. Overall, 395 were included, 144 male (M) 251 female (F). Mean age was 80.0 ± 8.4 years (M 76.7 ± 9.1, F 81.9 ± 7.3, p = 0.0000). points 22.9 ± 4.8 23.2 ± 4.6, 22.6 ± 5.0, p = 0.211). In total, 258 (65.3 %) used potential properties. Analgesics activity given to 117 (29.6 %). Low-potency opioids (tramadol hydrochloride, tilidine) identified 60 high-potency 57 patients. Antidepressants 66 patients, benzodiazepines 26, hypnotics 11, while 38 received other CNSADs. We only found significant correlations sedatives (diazepam oxazepam, Pearson’s r − 0.79, p = 0.05), but not lorazepam. Our an influence lorazepam) on users