Competition of the actions of antigen and polyclonal b-cell activator in the induction and amplification of b-memory cell function.

摘要: Using the capsular polysaccharide of Klebsiella pneumoniae (CPS-K) as a polyclonal B-cell activator (PBA) and sheep red blood cells (SRBC) T-dependent antigen, correlation actions PBA antigen on B in induction amplification immunological memory was studied. B-memory cell function, judged by anti-SRBC responsiveness vitro spleen CPS-K, amplified secondary injection SRBC into SRBC-primed mice, whereas it decreased markedly CPS-K. When CPS-K injected simultaneously with, or 1 2 days before SRBC, function also markedly. On other hand, did not inhibit when simultaneouly with primary SRBC. However, inhibited 3 The inhibition response to occurred mice primed 8 longer injection, detectable before. It is concluded that CPS-K-mediated signal SRBC-mediated act competitively same subpopulations memory, susceptibility negative changes correspondingly their maturation stage.